Reward Inhibits Paraventricular CRH Neurons to Relieve Stress
نویسندگان
چکیده
منابع مشابه
Hypothalamic CRH neurons orchestrate complex behaviours after stress
All organisms possess innate behavioural and physiological programmes that ensure survival. In order to have maximum adaptive benefit, these programmes must be sufficiently flexible to account for changes in the environment. Here we show that hypothalamic CRH neurons orchestrate an environmentally flexible repertoire of behaviours that emerge after acute stress in mice. Optical silencing of CRH...
متن کاملBrainstem catecholaminergic neurons activated by hypoxemia express GR and are coordinately activated with fetal sheep hypothalamic paraventricular CRH neurons.
In late gestation, challenges to fetal homeostasis are accompanied by increases in adrenocorticotropin (ACTH) concentrations in fetal peripheral plasma and Fos (c-fos protein) activation in corticotropin-releasing hormone (CRH) neurons of the fetal hypothalamic paraventricular nucleus (PVN). In adults, ventrolateral brainstem catecholaminergic (CA) neurons (A1/C1, A2/C2) project to the parvocel...
متن کاملAnchoring at an island to relieve stress.
S tress erythropoiesis is increasingly recognized as more than simply an expansion of steady-state erythropoiesis. Rather, it is a process arising from unique progenitor cells with distinct quantitative and qualitative cytokine requirements. Increased erythropoietin (Epo) levels resulting from kidney hypoxia due to anemia, initiate the response of stress erythropoiesis. A progenitor, named stre...
متن کاملCharacterization of Corticotropin-Releasing Hormone neurons in the Paraventricular Nucleus of the Hypothalamus of Crh-IRES-Cre Mutant Mice
Corticotropin-releasing hormone (CRH)-containing neurons in the paraventricular nucleus of the hypothalamus (PVN) initiate and control neuroendocrine responses to psychogenic and physical stress. Investigations into the physiology of CRH neurons, however, have been hampered by the lack of tools for adequately targeting or visualizing this cell population. Here we characterize CRH neurons in the...
متن کاملA Unique Population of Ventral Tegmental Area Neurons Inhibits the Lateral Habenula to Promote Reward
Lateral habenula (LHb) neurons convey aversive and negative reward conditions through potent indirect inhibition of ventral tegmental area (VTA) dopaminergic neurons. Although VTA dopaminergic neurons reciprocally project to the LHb, the electrophysiological properties and the behavioral consequences associated with selective manipulations of this circuit are unknown. Here, we identify an inhib...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Biology
سال: 2019
ISSN: 0960-9822
DOI: 10.1016/j.cub.2019.02.048